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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I suppose I put this product to the Ultimate Test! Two days before Hurricane Matthew hit my area I applied Wipe New to the heavily oxidized exterior Black Rubber trim and bumpers etc. on my Vintage 328 BMW. It set for 24 Hours and then the Hurricane hit us! I do not have a garage so car remained in our open Carport under our large Sundeck. Car was battered all day and night by Palm Tree debris and small limbs from Oak Trees and unbelievable squalls of heavy rain. Finally after 2 days the cleanup began. I sprayed off the car with water and the trim looks very good.. much better than before. No streaks and a even coat with no cracks or any problems. FYI, the car is fine too.. When I use Wipe New next for my Beach Truck I will make sure the Weather won't be potentially catastrophic.. anyway, this stuff works, watch the video make sure and follow all the specific directions and its true.. a little goes along way.
It charged my Iphone 5. Usually without running it through the battery back. Once I had to run through the battery pack when the iphone was completely drained. I was able to recharge the iPhone in 4 hours from 2 - 6 pm in full sunlight as long as panels were angled to receive full sun. It recharged my camera's perfectly as well. Great for beach, camping, and fishing