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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I hope that the producers of such cosmetics will finally clue in to the sad fact that the preservatives, notably the parabens, in their products can cause severe problems for the consumers who trust the advertisements that claim to be allergen-free. To someone who has gone into shock from methylparaben, that claim is not only a lie but also dangerous.
Sony nailed everything about this VR attachment. Ergonomically its spectacular. Its light but even so the headband holds all of it, so the googles don't press or hang on your face. The immersion is unreal especially in BattleZone, a game I played as a kid (yes I'm old :) ) It really is a unique sensation and puts you in the cockpit of a tank. I had no motion sickness just astonished sickness! I am buying that title first. One thing that I wasn't clear on was what game disk is included in the core set verses the launch bundle. It looks the same but there is a big difference you should be aware of. Both sets get the same free demos but the more expensive launch bundle actually contains the full $40 VR Worlds. The core bundle only lets to demo part of one of the games (Ocean exploration). The core calls this a demo of VR worlds but its next to nothing. I had the camera and motions from PS3 so I still saved $ getting the core set. Must Buy!
Seems like a good product, but not exactly what I was looking for. Was expecting something similar to cable, but it's more like a library of tv shows and movies online. Kind of set up like Netflix, really visually oriented interface. You can either browse the shows/movies by category or search for specific shows, then they take you to full episodes of the show or somewhere you can watch the movie for free.