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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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If you like Heart --- and in particular, this song, then you will love this version of it. I have an old iRiver that really does have some excellent sound and this digital remaster sounds beautiful on it.
Love Phil Collins songs, need to download more of his songs great to listen to! Original hate getting someone else's voice singing your fave singers songs
This stuff actually works. The only thing I don't like about it, is that it leaves white when it dries, I sprayed some slippers of mine cause I live in Washington where as you know it rains a lot and now the tops of them are white. Also it doesn't last that long but it is pretty cool.
The plastic is very hard with a textured surface, and their large plastic nameplate is not welcome, as I just wanted a comfortable mat. The hard surface is even further from a comfortable carpet that the car starts with. The fit of the molded pieces is OK but the overall size is too small to cover all the area one's shoes will be touching, such as the entry side and up into the foot well, which is pretty cheap for an expensive mat. Also, strangely for such a stiff material, the mats seem sticky and difficult to clean compared to a good quality rubber mat. The only possibly good feature is if you spill a drink squarely onto the small mat, it might be contained due to the upraised edges, which my wife likes, but the driver's side snaps holding the mat in place might leak? And those snaps make it difficult to take the mat in & out. What happened to good old heavy rubber mats?