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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 194.110.77.227, Europe, PL

    City: 21.0362 , Poland

  • Maricris Mendoza - Happy! Bye disgusting roaches!

    Wow. I can't believe it works!. We have some infestation of those disgusting German roaches, I'm out of my wits trying to kill them but they keep coming back. I spread the paste all over the kitchen counter, doors, cracks..and I was surprised after 1 week I barely see those creeters anymore. I would definitely buy this again for maintenance just to keep the roaches at bay

  • milkw0lves - My Holy Grail Shampoo

    This shampoo is really thick, and has a superbly thick lather. Finally, a shampoo that made me feel clean without making my hair feel dry. I took a shower (using the Oribe Signature Shampoo and Conditioner) at night, and seriously awoke with perfect, frizz-free hair. The shampoo also has a nice subtle, earthy scent, and the bottle looks really lovely in my bathroom!

  • K. Steele - Great for reducing bladder spasms

    I'm a 24yr old female with intermittent bladder issues. I have a small bladder, (had a sonogram and everything), I also have a minor issue with my bladder being able to tell my brain when I have to urinate sometimes though this is not often.

  • J. Danger - Works great

    Thick book, sturdy pages. Haven't read through the all of the text, but it provides interesting tidbits of info. I really got it for the clear front and back openings. It is easy to slide the plastic cover out to put in your quarters. Holds secure.

  • Michael Wild - Pretty good guide

    Frommer's did a nice job of summarizing the layout of Italy. Would like to see more hints on off the track, local favorites for seasoned travelers to Europe.

  • Averagejoe - It really works!!!

    I was skeptical about this. My Brother told me about a similar product. Not sure it is the same. You just spray it on and leave it. Sounds too good to be true. I have some real heavy duty Green Mold on the north side of my house. I spayed it on yesterday and it did not seem to work at first but then it turned all the green stuff into a lite tan color. Now I guess when it rains the residue will wash away. I have to say that I am impressed. The stuff I used last year turned black and looked terrible. This stuff looks great.

  • Gift Card - Not as good as my favorite.

    The store ran out of Spot Shot, so I tried this. It cost a little less too, but didn't do nearly the job my favorite does. It didn't get the stain out of the carpet easily. I had to really scrub after letting this set for quit some times.