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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Charles A. Wagoner - Great Smart TV Software, with Some Issues

    This TV is a great value, meaning that the price is fairly low, and the picture quality and software features are good-but-not-great. I don't have much to say about the picture quality. It's fine for what you pay. But I do want to focus on the smart TV software.

  • mommyof3 - These are great

    I needed the "right" b12 supplement according to my doctor and was unable to find anything in stores. I decided to give this a chance and am so glad that I did. I'm not a big vitamin person and honestly struggle to take even these daily. But, these are simple and taste great which makes these the most likely vitamin I would ever take! You don't need water to swallow them, the cherry flavored tablet simply melts in your mouth. I would say the closest thing to this would be sucking on a smarties candy (though those are smaller/harder in consistency). If you need a b12 supplement this is certainly worth a try, especially if you're proned to forgetting, as it is easy to take without the need for water!